血清反应阳性献血者中人类嗜T淋巴细胞病毒I型前病毒的定量分析：使用合成肽与抗体谱的关系。
Quantitation of HTLV-I provirus among seropositive blood donors: relation with antibody profile using synthetic peptides.
作者信息
Matsumura M, Kushida S, Ami Y, Suga T, Uchida K, Kameyama T, Terano A, Inoue Y, Shiraki H, Okochi K
机构信息
Department of Biochemistry, University of Tsukuba, Ibaraki, Japan.
出版信息
Int J Cancer. 1993 Sep 9;55(2):220-2. doi: 10.1002/ijc.2910550209.
To study the pathophysiological state of HTLV-I carriers and the quantitative aspect of the risk of HTLV-I infection, we measured the absolute amounts of HTLV-I provirus in 39 seropositive blood donors. The amount of provirus varied from less than one to more than 10(4) molecules per 10(5) peripheral-blood mononuclear cells (PBMC). The average amount of HTLV-I provirus among seropositive blood donors was estimated as 3.7 x 10(3) molecules per 10(5) PBMC. The titer of the antibody against only the synthetic peptide (aa 100 to 130) of the gag p19 region of the HTLV-I provirus showed a weak but significant correlation with the amount of the provirus.
为研究人类嗜T淋巴细胞病毒I型（HTLV-I）携带者的病理生理状态以及HTLV-I感染风险的定量情况，我们检测了39名血清阳性献血者体内HTLV-I前病毒的绝对含量。前病毒含量在每10⁵个外周血单个核细胞（PBMC）中从少于1个分子到超过10⁴个分子不等。血清阳性献血者中HTLV-I前病毒的平均含量估计为每10⁵个PBMC中有3.7×10³个分子。仅针对HTLV-I前病毒gag p19区域合成肽（氨基酸100至130）的抗体滴度与前病毒含量呈弱但显著的相关性。
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