Salvetti M, Buttinelli C, Massacesi L, Wekerle H
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
J Neuroimmunol. 1993 Sep;47(2):203-5. doi: 10.1016/0165-5728(93)90031-s.
This report discusses some of the papers presented during the 2nd T Cell Autoimmunity in MS Workshop held in Perugia on November 26-28, 1992. The 'trait d'union' of the meeting was the awareness that recent studies have failed to uncover clear-cut differences in T cell reactivity to autoantigens between patients with multiple sclerosis and healthy individuals. Hence, new strategies have been proposed to try to distinguish between 'pathological' autoimmunity in patients and 'natural' autoimmunity in healthy individuals. Furthermore, the studies have been extended to new potential autoantigens (myelin constituents other than myelin basic protein, superantigens, heat shock proteins) and new susceptibility genes such as those coding for transport-associated proteins (Tap-1 and Tap-2).
本报告讨论了1992年11月26日至28日在佩鲁贾举行的第二届多发性硬化症T细胞自身免疫研讨会上发表的一些论文。本次会议的“主旨”是意识到最近的研究未能揭示多发性硬化症患者与健康个体在T细胞对自身抗原反应性方面的明显差异。因此，人们提出了新的策略，试图区分患者的“病理性”自身免疫和健康个体的“自然”自身免疫。此外，研究已扩展到新的潜在自身抗原（除髓鞘碱性蛋白外的髓鞘成分、超抗原、热休克蛋白）以及新的易感基因，如编码转运相关蛋白的基因（Tap-1和Tap-2）。
