Khosla T, Newcombe R G, Campbell H
Br Med J. 1977 Feb 5;1(6057):341-4. doi: 10.1136/bmj.1.6057.341.
The Joint Working Party of the Royal College of Physicians and the British Cardiac Society have recently given advice to medical practitioners about preventing coronary heart disease. We have formulated an easy method by which the medical practitioner may apply a rule to identify individuals who are at moderate to high risk of developing the disease. The simple arithmetic requires finding the product of four numbers and can be done with a pocket calculator costing less than pound 10. The four numbers correspond to known values of the four risk variables--age, systolic blood pressure, serum cholesterol levels, and smoking--for a given individual. Tables of relative risk components for men aged 40 to 59 years for coronary heart disease defined by hard criteria (fatal or definite myocardial infarction) have been drawn up. The overall effect of the four risk variables is multiplicative so that some men aged 40 are at far greater risk than some of 55 year olds.
皇家内科医师学院和英国心脏病学会联合工作小组最近就预防冠心病向执业医师提供了建议。我们制定了一种简便方法，执业医师可据此运用一条规则来识别患该病风险处于中度至高度的个体。这个简单的算法需要算出四个数字的乘积，用一台价格不到10英镑的袖珍计算器就能完成。这四个数字对应给定个体的四个风险变量——年龄、收缩压、血清胆固醇水平和吸烟情况——的已知值。已经制定了40至59岁男性冠心病（根据严格标准定义，即致命性或确诊心肌梗死）相对风险成分表。这四个风险变量的总体影响是相乘的，因此一些40岁的男性患冠心病的风险比一些55岁的男性要高得多。
