Hennig B, Alvarado A
Department of Nutrition and Food Science, University of Kentucky, Lexington 40506-0054.
Prog Food Nutr Sci. 1993 Apr-Jun;17(2):119-57.
Loss of functional integrity of the vascular endothelium may be one of the initiating events in the etiology of atherosclerosis. Endothelial cells interact with blood components and the abluminal tissues, thus playing an active role in many aspects of vascular functions, such as permeability and vessel tone regulation. Endothelial cells constantly are exposed to nutrients which can modulate enzymes, receptors, transport molecules and various vasoactive mediators, resulting in significant functional changes of the endothelium and the underlying tissues. Nutrition may play an important role in the atherosclerotic disease process. There is evidence that certain vitamins and minerals prevent some metabolic and physiological perturbations of the vascular endothelium. This review focuses on selected lipids which cause endothelial cell injury or dysfunction and on nutrients which may exhibit antiatherogenic properties by being able to function as antioxidants or membrane stabilizers.
血管内皮功能完整性的丧失可能是动脉粥样硬化病因中的起始事件之一。内皮细胞与血液成分和血管外组织相互作用，从而在血管功能的许多方面发挥积极作用，如通透性和血管张力调节。内皮细胞持续暴露于可调节酶、受体、转运分子和各种血管活性介质的营养物质中，导致内皮及下层组织发生显著的功能变化。营养在动脉粥样硬化疾病过程中可能起重要作用。有证据表明，某些维生素和矿物质可预防血管内皮的一些代谢和生理紊乱。本综述重点关注导致内皮细胞损伤或功能障碍的特定脂质，以及可能通过充当抗氧化剂或膜稳定剂而具有抗动脉粥样硬化特性的营养物质。
