Hoffman P L, Walter R, Bulat M
Brain Res. 1977 Feb 11;122(1):87-94. doi: 10.1016/0006-8993(77)90664-3.
Vasopressin, other neurohpophyseal peptides and certain of their fragments can affect central nervous system function. Cyclo(Leu-Gly), formally derived from the C-terminal dipeptide of oxytocin, is also active in memory processes. This molecule, radioactively labeled for this study, was found to be resistant to enzymatic degradation both in vivo and in vitro. Furthermore, after its intravenous application in cat, it easily penetrated into cerebrospinal fluid. This indicates that cyclo(Leu-Gly) can readily pass from blood into the central nervous system to exert it's central pharmacological actions. Thus, labeled cyclo(Leu-Gly) is a valuable model for studying the distribution and localization of peptides which have activity in the central nervous system.
血管加压素、其他神经垂体肽及其某些片段可影响中枢神经系统功能。环（亮氨酸-甘氨酸），正式来源于催产素的C末端二肽，在记忆过程中也具有活性。该分子在本研究中用放射性标记，发现在体内和体外均对酶降解具有抗性。此外，在猫体内静脉注射后，它很容易渗透到脑脊液中。这表明环（亮氨酸-甘氨酸）可以很容易地从血液进入中枢神经系统，以发挥其中心药理作用。因此，标记的环（亮氨酸-甘氨酸）是研究在中枢神经系统中具有活性的肽的分布和定位的有价值模型。
