Chabot V
FMH en endocrinologie, anc. méd. adj. au CHUV, Lausanne.
Schweiz Rundsch Med Prax. 1993 Aug 10;82(32):858-63.
Already in 1988 Raeven mentioned a syndrome of resistance to insulin (X-syndrome). Before and after that description, several studies featured the central role of tissue resistance to the effects of endogenous insulin during development of diverse biological disturbances: adipositas, intolerance to glucose (or diabetes mellitus), arterial hypertension, dyslipidemia, atherosclerosis. The author summarizes the available literature on this 'new' syndrome that has hitherto not yet been accepted by all scientists. However, although data so far do not always coincide, many recent results give evidence for the importance of the role of a fateful span: resistance to insulin (probably of genetic origin) and secondary hyperinsulinemia. Their role in the genesis of the above-mentioned clinical disturbances is described, as measures for 'physiological' therapy are stressed: strict diet and regular physical exercises. If these simple measures fail, special drugs may be effective.
早在1988年,雷文就提到了胰岛素抵抗综合征(X综合征)。在该描述之前和之后,多项研究都强调了组织对内源性胰岛素作用的抵抗在多种生物紊乱发展过程中的核心作用:肥胖、葡萄糖不耐受(或糖尿病)、动脉高血压、血脂异常、动脉粥样硬化。作者总结了关于这种“新”综合征的现有文献,该综合征迄今尚未被所有科学家接受。然而,尽管目前的数据并不总是一致,但许多近期结果证明了一个关键阶段的重要性:胰岛素抵抗(可能源于遗传)和继发性高胰岛素血症。文中描述了它们在上述临床紊乱发生过程中的作用,并强调了“生理性”治疗措施:严格的饮食和规律的体育锻炼。如果这些简单措施无效,特殊药物可能会有效。