Kostiuk E p, Zubkova S T
Fiziol Zh (1978). 1993 Sep-Dec;39(5-6):93-8.
The review summarizes data about interconnection between atherosclerosis and diabetes mellitus. Special attention is paid to their joint developmental factors such as hyperinsulinemia and insulin resistance. It is shown that hyperinsulinemia may form an independent risk factor. At the same time both factors can lead (during both diabetes mellitus and atherosclerosis) to changes in lipid metabolism and development of atheroms. Mechanisms of the development of insulin resistance and hyperinsulinemia are analyzed. The so-called syndrome X is described in detail. It is characterized by a triad of changes: insulin resistance and hyperinsulinemia, changes in lipid metabolism and hypertension. Some methods of treatment of insulin resistance and hyperinsulinemia during atherosclerosis and diabetes mellitus are described.
本综述总结了有关动脉粥样硬化与糖尿病之间相互联系的数据。特别关注了它们共同的发展因素，如高胰岛素血症和胰岛素抵抗。研究表明，高胰岛素血症可能构成一个独立的危险因素。同时，这两个因素（在糖尿病和动脉粥样硬化过程中）均可导致脂质代谢变化和动脉粥样硬化的发展。分析了胰岛素抵抗和高胰岛素血症的发生机制。详细描述了所谓的X综合征。其特征为一组三联征变化：胰岛素抵抗和高胰岛素血症、脂质代谢变化及高血压。还介绍了在动脉粥样硬化和糖尿病期间治疗胰岛素抵抗和高胰岛素血症的一些方法。
