Sasportes M, Fradelizi D, Dausset J
Transplant Proc. 1978 Dec;10(4):905-9.
In conclusion, DR-specific suppressor cells can be induced by repeated in vitro sensitizations. They were able (1) to decrease a secondary proliferation, (2) to suppress consistently, in a primary proliferative assay, when added as third cells (primed twice against a DR antigen [PLT II] and gamma-irradiated), the response of unprimed cells towards stimulating cells, which share a DR specificity with the priming cell of the PLT II. The suppression follows the D part of the recombinant haplotype within an HLA-B/D recombinant family and is specific for the DR antigen used twice as stimulator for production of the PLT II.
总之，通过体外反复致敏可诱导出DR特异性抑制细胞。它们能够：（1）降低二次增殖；（2）在初次增殖试验中，当作为第三种细胞（针对DR抗原[血小板II]进行两次致敏并经γ射线照射）添加时，持续抑制未致敏细胞对与血小板II致敏细胞具有相同DR特异性的刺激细胞的反应。在一个HLA - B/D重组家族中，抑制作用遵循重组单倍型的D部分，并且对作为刺激物用于产生血小板II的DR抗原具有特异性。
