双基因与内分泌疾病：CYP21基因和CYP11B基因
Twin genes and endocrine disease: CYP21 and CYP11B genes.
作者信息
Helmberg A
机构信息
Department of Molecular Biology, University of Innsbruck Medical School, Austria.
出版信息
Acta Endocrinol (Copenh). 1993 Aug;129(2):97-108. doi: 10.1530/acta.0.1290097.
PMID:8372604
Abstract
CYP21 and CYP11B genes have a common feature: they are "twin" genes. It seems as if doubling and subsequent drifting apart rendered these genes particularly sensitive to defect acquisition by mechanisms involving recombinatorial events. This creates specific difficulties in the molecular diagnosis of defects.
摘要
CYP21和CYP11B基因有一个共同特征：它们是“孪生”基因。似乎基因加倍以及随后的分化使这些基因对涉及重组事件的机制导致的缺陷获得特别敏感。这给缺陷的分子诊断带来了特殊困难。
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