Toxicity of antimalarial drugs in rheumatoid arthritis.

Antimalarials have the lowest incidence of toxicity among the disease modifying antirheumatic drugs (DMARDs). Low daily dose and regular ophthalmologic examination has minimised potential retinopathy. Some toxicity may be related to the lysosomotropic action of antimalarials. DMARD toxicity may affect the variability in response to antirheumatic drugs.