Badalian S S, Chao C R, Fox H E, Timor-Tritsch I E
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Am J Obstet Gynecol. 1993 Sep;169(3):563-7. doi: 10.1016/0002-9378(93)90621-o.
Our purpose was to determine the Doppler ultrasonographic characteristics of fetal breathing-related nasal fluid flow velocity in uncomplicated pregnancies.
Fetal nasal flow velocity was studied in 52 uncomplicated pregnancies at gestational ages ranging from 22 to 41 weeks. The evaluation of fetal breathing-related nasal fluid flow velocity was performed with ultrasonography combined with color flow and spectral Doppler analysis.
The study revealed that the breath-to-breath interval and duration of the inspiratory phase of the fetal breathing-related nasal flow increased from 22 to 35 weeks and decreased thereafter. The breath-to-breath interval (milliseconds) at 33 to 35 weeks (1203.9 +/- 295.7 SD) was approximately twice what it was in the earliest age group (22 to 25 weeks); subsequently it decreased by approximately 25% in the term group (38 to 41 weeks). A positive correlation existed between the mean breathing-related nasal peak inspiratory flow velocity and advancing gestational age (r = 0.56, p = 0.0008), and between the inspiratory flow velocity acceleration and advancing gestational age (r = 0.53, p = 0.0076).
Changes in fetal breathing activity during uncomplicated pregnancies can be determined by measurement of fetal breathing-related nasal fluid flow velocity. Our observations in uncomplicated pregnancies may be useful in future studies of these parameters in complicated pregnancies such as those at risk for pulmonary hypoplasia.
我们的目的是确定正常妊娠中与胎儿呼吸相关的鼻液流速的多普勒超声特征。
对52例孕周在22至41周的正常妊娠进行胎儿鼻流速研究。采用超声检查结合彩色血流和频谱多普勒分析对与胎儿呼吸相关的鼻液流速进行评估。
研究显示，与胎儿呼吸相关的鼻气流的呼吸间隔和吸气期持续时间从22周增加至35周，之后减少。33至35周时的呼吸间隔（毫秒）（1203.9±295.7标准差）约为最早年龄组（22至25周）的两倍；随后，足月组（38至41周）下降了约25%。与呼吸相关的鼻平均吸气峰流速与孕周增加呈正相关（r = 0.56，p = 0.0008），吸气流速加速度与孕周增加也呈正相关（r = 0.53，p = 0.0076）。
通过测量与胎儿呼吸相关的鼻液流速可确定正常妊娠期间胎儿呼吸活动的变化。我们对正常妊娠的观察结果可能有助于未来对复杂妊娠（如肺发育不全风险妊娠）中这些参数的研究。
