Inoue Y, Akiyama M, Hashine K, Sumiyoshi Y
Dept. of Urology, Shikoku Cancer Center.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1686-8.
Eleven patients with prostate cancer were treated by intra-arterial infusion chemotherapy and radiotherapy combined with hormone therapy. CDDP was given one patient, THP and CDDP to eight patients, and THP and CBDCA to two others. All patients were treated by whole pelvis with prostate boost radiation. Seven patients underwent castration and four were administered LH-RH agonist in hormone therapy. Clinically, CR was observed in two patients and PR in nine. Histologically, G3 was observed in six patients, G2 in four patients and G1 in one. The main side effects were myelosuppression and rectal disturbances, but treatment could be completed in all patients. These results suggest that this treatment is a useful regimen for prostate cancer.
11例前列腺癌患者接受了动脉内灌注化疗、放疗联合激素治疗。1例患者给予顺铂，8例患者给予吡柔比星和顺铂，另外2例患者给予吡柔比星和卡铂。所有患者均接受全盆腔加前列腺局部增强放疗。7例患者接受去势治疗，4例患者在激素治疗中给予促黄体生成素释放激素激动剂。临床上，2例患者观察到完全缓解（CR），9例患者观察到部分缓解（PR）。组织学上，6例患者为G3，4例患者为G2，1例患者为G1。主要副作用为骨髓抑制和直肠功能紊乱，但所有患者均能完成治疗。这些结果表明，这种治疗方法是前列腺癌的一种有效治疗方案。
