Savlov E D, Wittliff J L, Hilf R
Cancer. 1977 Feb;39(2):539-41. doi: 10.1002/1097-0142(197702)39:2<539::aid-cncr2820390223>3.0.co;2-a.
This report extends our observations on the relationship between the therapy of breast cancer, estrogen binding and tissue enzymes. We have compared the dextran-coated charcoal method and the sucrose gradient analysis in determining estrogen receptors, and find a sub-group of receptor positive tumors--identifiable only by the latter technique--which we suggest may lead to an incorrect prediction of response to hormonal therapy. Data are also presented to suggest that enzyme analyses show promise in predicting responsiveness to present modes of combination chemotherapy of breast cancer.
本报告扩展了我们对乳腺癌治疗、雌激素结合与组织酶之间关系的观察。我们比较了葡聚糖包被活性炭法和蔗糖梯度分析法在测定雌激素受体方面的情况，发现了一组仅能通过后一种技术识别的受体阳性肿瘤亚群，我们认为这可能会导致对激素治疗反应的错误预测。同时还提供了数据表明酶分析在预测乳腺癌目前联合化疗模式的反应性方面具有前景。
