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生物膜的程序性脂质过氧化产生扭结的磷脂,允许局部分子移动:流动性管理的过氧化理论。

Programmed lipid peroxidation of biomembranes generating kinked phospholipids permitting local molecular mobility: a peroxidative theory of fluidity management.

作者信息

Jain S, Thomas M, Kumar G P, Laloraya M

机构信息

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

出版信息

Biochem Biophys Res Commun. 1993 Sep 15;195(2):574-80. doi: 10.1006/bbrc.1993.2084.

DOI:10.1006/bbrc.1993.2084
PMID:8373398
Abstract

The lipid peroxidation profiles in the uterus of mature mice show cyclic alterations during the reproductive cycle. Similarly, during early pregnancy, alterations in lipid peroxidation are evident, keeping close pace with the superoxide anion radical levels and fluidity parameters reported elsewhere. This formulates a theory that a 'controlled' lipid peroxidation of biomembrane terminating at the accumulation of cyclic endoperoxides could rather enhance local molecular mobility because of the increased inter-molecular distance in these 'kinked-species'.

摘要

成熟小鼠子宫中的脂质过氧化谱在生殖周期中呈现周期性变化。同样,在妊娠早期,脂质过氧化的变化也很明显,与其他地方报道的超氧阴离子自由基水平和流动性参数密切相关。这就形成了一种理论,即生物膜的“受控”脂质过氧化在环状内过氧化物积累时终止,由于这些“扭结物种”中分子间距离增加,反而可能增强局部分子流动性。

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