Tapia-Rombo C A, Velasco-Lavín M R, Nieto-Caldelas A
Servicio de Neonatalogía, Hospital General, México, D.F., México.
Bol Med Hosp Infant Mex. 1993 Sep;50(9):650-4.
The purpose of the present study is to compare risk factors of necrotizing enterocolitis (NEC) between two group: group A, newborns with the disease and group B, newborns with other diseases different from NEC, in order to know if these risk factors are more frequent or not in the first group. We assessed the clinical records of all the patients hospitalized in the Neonatal Intensive Care Unit and Neonatology Service of the La Raza General Hospital between 1987 and 1991 with the diagnosis of NEC. They were compared with 65 clinical records chosen at random of patients hospitalized in the same Unit with other diagnosis at the same time, and who were discharged by improvement or deceased. In all of them were look for known risk factors for NEC generally accepted such as: prematurity, neonatal asphyxia, poliglobulia, cyanotic congenital heart disease, patent ductus arteriosus, respiratory distress syndrome, catheterization of umbilical vessels, early feeding of elevated formula increases, exchange exchange transfusion, hypoxic ischemic encephalopathy, infection, etc. Just 25 records of the possible 50 with the diagnosis of NEC full filled inclusion criteria. There were no statistically significant difference in weight, sex, mortality and known risk factors of NEC between both groups. Were concluded that NEC is a disease of unknown etiology that should be studied more thoroughly. The known risk factors must be avoided because the patient susceptibility probably play an important role.
本研究的目的是比较两组之间坏死性小肠结肠炎(NEC)的危险因素:A组为患有该疾病的新生儿,B组为患有不同于NEC的其他疾病的新生儿,以便了解这些危险因素在第一组中是否更常见。我们评估了1987年至1991年期间在拉腊扎综合医院新生儿重症监护病房和新生儿科住院且诊断为NEC的所有患者的临床记录。将他们与同时在同一病房因其他诊断住院且已好转出院或死亡的65例随机选择的患者的临床记录进行比较。在所有这些记录中寻找一般公认的NEC已知危险因素,如:早产、新生儿窒息、红细胞增多症、青紫型先天性心脏病、动脉导管未闭、呼吸窘迫综合征、脐血管插管、早期高配方奶喂养、换血、缺氧缺血性脑病、感染等。在可能的50例诊断为NEC的记录中,只有25例符合纳入标准。两组之间在体重、性别、死亡率和NEC已知危险因素方面无统计学显著差异。得出的结论是,NEC是一种病因不明的疾病,应进行更深入的研究。必须避免已知的危险因素,因为患者的易感性可能起重要作用。