Peterson J B, Pihl R O, Séguin J R, Finn P R, Stewart S H
Department of Psychology, McGill University, Montreal, Quebec, Canada.
J Psychiatry Neurosci. 1993 Jul;18(4):190-8.
Recent studies have demonstrated that sons of male alcoholics with multigenerational family histories of male alcoholism are characterized by sober heart-rate hyperreactivity to aversive stimuli, susceptibility to alcohol-induced dampening of that hyperreactivity and by increased resting heart rate while intoxicated. Regression analyses indicate that the magnitude of alcohol-induced change in resting and reactive cardiac response is significantly and powerfully associated with the degree of self-reported voluntary alcohol consumption among 85 non-alcoholic males who are either lacking or who have moderate or extensive family histories of male alcoholism. It appears that heightened sensitivity to alcohol-induced increase in resting and decrease in reactive heart rate might mark or underlie familial risk for developing alcoholism.
最近的研究表明，有男性酗酒多代家族史的男性酗酒者的儿子具有以下特征：对厌恶刺激的静息心率反应过度清醒，易受酒精诱导的该反应过度减弱的影响，以及在醉酒时静息心率增加。回归分析表明，在85名没有或有中度或广泛男性酗酒家族史的非酒精性男性中，酒精诱导的静息和反应性心脏反应变化的幅度与自我报告的自愿饮酒程度显著且强烈相关。似乎对酒精诱导的静息心率增加和反应性心率降低的敏感性增强可能标志着或构成发展为酒精中毒的家族风险。
