Collado-Vides J
Centro de Investigación sobre Fijación de Nitrógeno, Universidad Nacional Autónoma de México, Cuernavaca, Morelos.
Biosystems. 1993;29(2-3):105-28. doi: 10.1016/0303-2647(93)90087-s.
The goal of this paper and the accompanying one is to achieve a linguistic representation of a set of sigma 70 promoters. Such a description is formed by an ordered concatenated array of complex symbols identified by their categorical property, i.e. promoter, operator, activator binding site, etc. Each of these symbols may contain several properties associated with their respective classes of 'molecular words'. The main problem in attaining such a description is to define which properties are going to be represented, and how. In the accompanying paper the criteria on which the selection of alternative descriptions is based were discussed. The properties of promoters and regulatory sites are discussed here, and their corresponding distinctive features are selected following such criteria. Thus, information that is not directly relevant and that can overspecify the description has been excluded, since it does not seem to contribute to identifying classes of substitutable elements. Other properties, such as strength of promoters, position of regulatory sites, different types of specificities of regulatory proteins, affinity of their binding sites, etc., are also discussed. As a result of this analysis, a complete representation with distinctive features of the set of sigma 70 promoters is attainable.
本文以及与之相关的另一篇论文的目标是实现对一组σ70启动子的语言表述。这样的描述由一系列复杂符号按顺序串联而成，这些符号根据其类别属性来确定，即启动子、操纵子、激活剂结合位点等。这些符号中的每一个都可能包含与其各自“分子词汇”类别相关的若干属性。实现这样一种描述的主要问题在于确定要表示哪些属性以及如何表示。在相关论文中讨论了选择替代描述所依据的标准。这里讨论启动子和调控位点的属性，并按照这些标准选择它们相应的独特特征。因此，那些不直接相关且可能过度限定描述的信息已被排除，因为它似乎对识别可替代元件的类别没有帮助。还讨论了其他属性，如启动子的强度、调控位点的位置、调控蛋白不同类型的特异性、它们结合位点的亲和力等。经过这一分析，就可以实现对σ70启动子集合具有独特特征的完整表述。
