Kuznetsova L V, Medvedeva N A, Medvedev O S
Biull Eksp Biol Med. 1993 Jun;115(6):594-6.
The hemodynamic effect of combined V2/V1 arginine vasopressin (AVP) antagonist in conscious rats with acute 24 hour streptozotocin (STZ)--induced diabetes was studied using the microsphere technique. The rats were made diabetic with a single intravenous injection of STZ (60 mg/kg). One day after STZ administration the hemodynamic parameters in the experimental animals were measured before and 10 minutes after AVP antagonist injection (50 mg/kg, i.v.). The hemodynamic alterations observed post-antagonist included: 1) an increase in the total peripheral resistance (1.84 +/- 0.15 vs. 1.31 +/- 0.12 mm Hg/ml/min per 100 g before antagonist administration, p < 0.05), 2) a decrease in the cardiac index (49.0 +/- 3.1 vs. 68.7 +/- 5.2 ml/min/100 g before antagonist administration, p < 0.05) and stroke volume (0.40 +/- 0.03 vs. 0.57 +/- 0.06 ml before antagonist administration, p < 0.05), 3) a significant (p < 0.05) decrease in the blood flow to the skin, skeletal muscle, stomach, small intestine and kidneys. The mean arterial pressure and heart rate remained unchangeable post-antagonist. These data suggest that AVP is responsible, at least in part, for prominent hemodynamic alterations observed in conscious rats with 24 hour STZ-induced diabetes.
采用微球技术研究了V2/V1精氨酸加压素（AVP）联合拮抗剂对急性链脲佐菌素（STZ）诱导糖尿病清醒大鼠的血流动力学影响。通过单次静脉注射STZ（60mg/kg）使大鼠患糖尿病。在给予STZ一天后，测量实验动物在注射AVP拮抗剂（50mg/kg，静脉注射）前和注射后10分钟的血流动力学参数。拮抗剂注射后观察到的血流动力学改变包括：1）总外周阻力增加（拮抗剂给药前为1.31±0.12mmHg/ml/min per 100g，给药后为1.84±0.15，p<0.05），2）心脏指数降低（拮抗剂给药前为68.7±5.2ml/min/100g，给药后为49.0±3.1，p<0.05）和每搏输出量降低（拮抗剂给药前为0.57±0.06ml，给药后为0.40±0.03，p<0.05），3）皮肤、骨骼肌、胃、小肠和肾脏的血流量显著降低（p<0.05）。拮抗剂注射后平均动脉压和心率保持不变。这些数据表明，AVP至少在一定程度上导致了24小时STZ诱导糖尿病清醒大鼠中观察到的显著血流动力学改变。
