Karlberg J, Gelander L, Albertsson-Wikland K
Department of Pediatrics, Queen Mary Hospital, University of Hong Kong.
Acta Paediatr. 1993 Aug;82(8):631-4. doi: 10.1111/j.1651-2227.1993.tb18029.x.
It is known what the aim is in a complete long-term growth study; the final height is the outcome measure, although the annual height velocity values provide additional information. Strictly, short-term growth studies are also defined in terms of minimum length of observation, i.e. one month, as well as the type of measurement errors to be considered. The poor correlation between short- and long-term growth velocity values has led to the conclusion that the short-term study cannot be interpreted in long-term perspectives, and vice versa. There is a need to debate the way in which results of short-term studies should be interpreted. This is especially important when short-term growth is taken as the outcome measure in a controlled study. Our proposal is that such studies must include information about the growth achieved for a period after the treatment has ended in order to describe possible compensatory growth. Without weighing in some long-term consequences, we may incorrectly document short-term growth as a positive or negative effect of a certain treatment.
在一项完整的长期生长研究中，目标是明确的；最终身高是结果指标，尽管年身高增长速度值能提供额外信息。严格来说，短期生长研究也是根据最短观察时长（即一个月）以及要考虑的测量误差类型来定义的。短期和长期生长速度值之间的低相关性已得出这样的结论：短期研究不能从长期角度进行解读，反之亦然。有必要对短期研究结果的解读方式展开讨论。当在对照研究中将短期生长作为结果指标时，这一点尤为重要。我们的建议是，此类研究必须包含治疗结束后一段时间内所实现生长情况的信息，以便描述可能的代偿性生长。如果不权衡一些长期后果，我们可能会错误地将短期生长记录为某种治疗的正面或负面影响。
