Salai M, Langevitz P, Blankstein A, Zemmer D, Chechick A, Pras M, Horoszowski H
Department of Orthopaedic Surgery, Chaim Sheba Medical Center, Tel-Hashomer Hospital, Tel Aviv, Israel.
Bull Hosp Jt Dis. 1993 Spring;53(1):25-8.
Familial Mediterranean fever (FMF) is a hereditary disorder affecting people of Mediterranean stock, mainly Sephardic Jews and Armenians. It is characterized by attacks of arthritis, either short, self-limited episodes typically lasting 72 hours or protracted attacks lasting from two weeks to one year. The latter form affects mainly the large joints of the lower limb. The hip joint is the most vulnerable and likely to be affected by the protracted attacks, which may result in destruction of the articular cartilage and, in some cases, aseptic necrosis of the femoral head. Eighteen FMF patients (19-52 years) underwent 22 total hip replacements between 1971 and 1985 at our hospital. Six of the 18 initial prostheses experienced aseptic loosening. This relatively high incidence led us to recommend implantation of cementless hip prostheses following meticulous synovectomy as the treatment of choice. The results of these surgeries and the uniqueness of total hip replacement in FMF patients are presented here and discussed.
家族性地中海热（FMF）是一种遗传性疾病，主要影响地中海血统的人群，尤其是西班牙系犹太人及亚美尼亚人。其特征为关节炎发作，发作形式有两种：一是短暂的、通常持续72小时的自限性发作；二是持续两周至一年的迁延性发作。后一种形式主要影响下肢大关节。髋关节最易受累且很可能受到迁延性发作的影响，这可能导致关节软骨破坏，在某些情况下还会导致股骨头无菌性坏死。1971年至1985年间，我院有18例FMF患者（年龄19 - 52岁）接受了22次全髋关节置换术。18个初始假体中有6个出现无菌性松动。这种相对较高的发生率使我们建议，在进行细致的滑膜切除术后，植入非骨水泥型髋关节假体作为首选治疗方法。本文介绍并讨论了这些手术的结果以及FMF患者全髋关节置换术的独特之处。
