一例膀胱移行细胞癌伴9号染色体长臂（q）11至21.2区域缺失。
A case of transitional cell carcinoma of the bladder with a del(9)(q11q21.2).
作者信息
Bernués M, Casadevall C, Miró R, Caballín M R, Gelabert A, Egozcue J
机构信息
Institut de Biologia Fonamental Vincent Villar Palasí, Universitat Autònoma de Barcelona, Bellaterra, Spain.
出版信息
Cancer Genet Cytogenet. 1993 Aug;69(1):76-7. doi: 10.1016/0165-4608(93)90120-b.
Monosomy for chromosome 9, as well as loss of heterozygosity for markers on this chromosome, has been detected in a high percentage of transitional cell carcinomas (TCC) of the bladder. We report a case of a TCC of the bladder with an interstitial del(9)(q11q21.2) that could be indicative of the presence of a putative tumor-suppressor gene related to bladder tumor progression. To elucidate the role of chromosome 9 in bladder tumors, it would be interesting to study a possible loss of heterozygosity in this chromosome region.
在高比例的膀胱移行细胞癌（TCC）中已检测到9号染色体单体性以及该染色体上标记的杂合性缺失。我们报告了一例膀胱TCC病例，其存在间质del(9)(q11q21.2)，这可能表明存在一个与膀胱肿瘤进展相关的假定肿瘤抑制基因。为阐明9号染色体在膀胱肿瘤中的作用，研究该染色体区域可能存在的杂合性缺失将很有意义。
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