Yuri M, Tokumoto M, Hara N, Fujimoto Y, Kobayashi N, Morisaki M
Department of Chemistry, Tokyo Institute of Technology, Japan.
Chem Pharm Bull (Tokyo). 1993 Jul;41(7):1327-9. doi: 10.1248/cpb.41.1327.
Incubation of [27-13C]-3 alpha, 7 alpha, 12 alpha-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by 13C-NMR analysis of the incubation product has resulted in the identification of [26-13C]-27-nor-3 alpha, 7 alpha, 12 alpha-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3 alpha, 7 alpha, 12 alpha-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.
将[27-¹³C]-3α,7α,12α-三羟基-24-烯-26-前列腺酸与大鼠肝脏匀浆一起孵育，然后对孵育产物进行¹³C-NMR分析，结果鉴定出了[26-¹³C]-27-降-3α,7α,12α-三羟基-24-氧代胆甾烷酮，这支持了底物已被代谢为3α,7α,12α-三羟基-24-氧代-26-前列腺酸辅酶A衍生物的观点。
