Iwakiri K, Kobayashi M, Sesoko M, Nomura T
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Gastroenterol Jpn. 1993 Aug;28(4):477-82. doi: 10.1007/BF02776944.
Gastroesophageal reflux (GER) and esophageal motility were evaluated in patients with esophageal varices (EV). This study comprised 35 patients with EV, 18 patients with reflux esophagitis (RE) and 12 healthy volunteers. EV were classified according to the F factor by the Endoscopic Classification of EV of the Japanese Research Society for Portal Hypertension. The lower esophageal sphincter (LES) function in the F3 group was significantly decreased and similar to that in the RE group. The amplitude of primary peristalsis at the site of F2 or F3 EV was significantly decreased. Acid clearance was significantly delayed in the F2 and F3 groups compared to that in the healthy subjects. GER was suppressed by the presence of F3 EV and was significantly decreased in this group compared to that in the healthy subjects. An antireflux barrier is concluded to be maintained in patients with F3 EV.
对食管静脉曲张（EV）患者的胃食管反流（GER）和食管动力进行了评估。本研究包括35例EV患者、18例反流性食管炎（RE）患者和12名健康志愿者。根据日本门静脉高压研究学会的EV内镜分类法，依据F因子对EV进行分类。F3组的食管下括约肌（LES）功能显著降低，与RE组相似。F2或F3级EV部位的原发性蠕动幅度显著降低。与健康受试者相比，F2组和F3组的酸清除明显延迟。F3级EV的存在抑制了GER，与健康受试者相比，该组的GER显著降低。得出结论，F3级EV患者存在抗反流屏障。
