Marcove R C, Stovell P B, Huvos A G, Bullough P G
Clin Orthop Relat Res. 1977 Jan-Feb(122):147-56.
Eighteen chondrosarcoma (Grade I and Grade II) have been treated with cryosurgery. One patient subsequently developed a metastasis; three later had to have an en bloc resection (in two of these there was no tumor in the specimen) and three underwent amputation (one of these had tumor in the specimen). In general, cryosurgery for low grade chondrosarcoma is encouraging as long as the limb is protected postoperatively from fracture -- using various orthopedic appliances to allow bone regeneration (i.e. ischial weight bearing brace). Other complications such as nerve paralysis have been transient. One air embolis death occurred (in another disease) where the exit of nitrogen gas was blocked. This is preventable by allowing free exit of gas from the bone. Approximately 500 cases of primary bone have been treated with cryosurgery as of this date; long term follow-up results will be reported later.
18例（I级和II级）软骨肉瘤患者接受了冷冻手术治疗。1例患者随后出现转移；3例后来不得不进行整块切除（其中2例标本中无肿瘤），3例接受了截肢手术（其中1例标本中有肿瘤）。一般来说，只要术后使用各种矫形器具保护肢体免受骨折，以促进骨再生（如坐骨承重支具），冷冻手术治疗低级别软骨肉瘤的效果是令人鼓舞的。其他并发症如神经麻痹都是暂时的。发生了1例空气栓塞死亡（在另一种疾病中），原因是氮气排出受阻。通过让气体从骨中自由排出可预防这种情况。截至目前，约500例原发性骨病患者接受了冷冻手术治疗；长期随访结果将在以后报告。
