Neidel J, Boddenberg B, Zander D, Schicha H, Rütt J, Hackenbroch M H
Clinic for Orthopaedics, University of Cologne, Germany.
J Pediatr Orthop. 1993 Sep-Oct;13(5):592-7.
Thyroid function was studied in 59 consecutive children with Legg-Calvé-Perthes disease (LCPD) and 239 controls. The subjects of both groups were generally euthyroid. In the Perthes group, however, plasma concentrations of free thyroxin (FT4) were increased by 16% (p < 10(-8)) and those of free triiodothyronine (FT3) were increased by 10% (p < 0.001) as compared with controls. There was a tendency toward higher FT4 levels in children with necrosis of more than one half of the femoral head (p < 0.015), as compared with those with lesser involvement. The observed moderate hormonal changes were already evident at the time of diagnosis of LCPD and were not appreciably influenced by stage of disease or mode of treatment, as determined by longitudinal evaluation of 38 children. Our data may support the assumption of other investigators that systemic abnormalities exist in children with LCPD, but the relation between these findings and the femoral head necrosis is not known.
对59例连续性Legg-Calvé-Perthes病（LCPD）患儿和239名对照儿童的甲状腺功能进行了研究。两组受试者甲状腺功能一般均正常。然而，与对照组相比，Perthes病组的游离甲状腺素（FT4）血浆浓度升高了16%（p < 10(-8)），游离三碘甲状腺原氨酸（FT3）血浆浓度升高了10%（p < 0.001）。与股骨头受累程度较轻的儿童相比，股骨头坏死超过一半的儿童FT4水平有升高趋势（p < 0.015）。通过对38名儿童的纵向评估确定，观察到的适度激素变化在LCPD诊断时就已很明显，且不受疾病阶段或治疗方式的明显影响。我们的数据可能支持其他研究者的假设，即LCPD患儿存在全身异常，但这些发现与股骨头坏死之间的关系尚不清楚。
