Poli L, Zanocchi M, Bo M, Fonte G, Fabris F
Department of Geriatric Medicine, University of Turin, Italy.
Int Angiol. 1993 Mar;12(1):13-20.
The carotid and femoral arteries of 209 subjects (161 men and 48 women), consecutively tested by coronary angiography during the first four months of 1990, were examined using a B-Mode Echo-doppler. The angiographic examination was performed for suspected ischemic disease or to complement hemodynamic tests for valvular cardiopathy. The relationship between the main risk factors and the degree of atherosclerotic vascular involvement in the coronary, carotid and femoral districts was examined using standardised partial correlation coefficients. Cigarette smoke (expressed as number of cigarettes per day or as duration of exposure to smoke), total blood cholesterol concentration and age were positively correlated with the degree of atherosclerotic involvement in all three vascular regions; triglyceridemia values were correlated only in the coronary region. These relations were observed both in patients below and above 65 years of age; in the elderly group no correlation was found between blood cholesterol concentration and coronary involvement and between triglycerides levels and atherosclerotic disease in the three districts. Our results suggest that some risk factors (high blood cholesterol concentration and history of smoking) correlate with severity of atherosclerotic involvement even in advanced age.
在1990年的前四个月期间，对209名受试者（161名男性和48名女性）的颈动脉和股动脉进行了连续的冠状动脉造影检查，并使用B型超声多普勒进行了检查。血管造影检查是针对疑似缺血性疾病进行的，或用于补充瓣膜性心脏病的血流动力学检查。使用标准化偏相关系数检查了主要危险因素与冠状动脉、颈动脉和股动脉区域动脉粥样硬化血管受累程度之间的关系。吸烟（以每日吸烟支数或吸烟暴露时间表示）、总血胆固醇浓度和年龄与所有三个血管区域的动脉粥样硬化受累程度呈正相关；甘油三酯值仅与冠状动脉区域相关。在65岁以下和65岁以上的患者中均观察到了这些关系；在老年组中，未发现血胆固醇浓度与冠状动脉受累之间以及甘油三酯水平与三个区域的动脉粥样硬化疾病之间存在相关性。我们的结果表明，即使在高龄人群中，一些危险因素（高血胆固醇浓度和吸烟史）也与动脉粥样硬化受累的严重程度相关。
