细小病毒B19 NS1基因产物对1型人类免疫缺陷病毒长末端重复序列的反式激活作用。
Trans-activation of the long terminal repeat of human immunodeficiency virus type 1 by the parvovirus B19 NS1 gene product.
作者信息
Sol N, Morinet F, Alizon M, Hazan U
机构信息
Service de Bactériologie et Virologie, Hôpital Saint-Louis, Paris, France.
出版信息
J Gen Virol. 1993 Sep;74 ( Pt 9):2011-4. doi: 10.1099/0022-1317-74-9-2011.
Persistent parvovirus B19 infections in human immunodeficiency virus type 1 (HIV-1)-infected patients have been reported. The two viruses could share common target cells. The NS1 protein of B19 regulates B19 expression and we have investigated its possible effect on the long terminal repeat (LTR) of HIV-1. In transient transfection experiments, NS1 trans-activated the expression of reporter genes under the control of the HIV-1 LTR. The effect of NS1 was apparent only in the presence of the HIV-1 Tat protein, and required intact TAR and TATA box sequences.
据报道，在感染了1型人类免疫缺陷病毒（HIV-1）的患者中存在持续性B19细小病毒感染。这两种病毒可能共享共同的靶细胞。B19的NS1蛋白调节B19的表达，我们研究了其对HIV-1长末端重复序列（LTR）可能产生的影响。在瞬时转染实验中，NS1反式激活了受HIV-1 LTR控制的报告基因的表达。NS1的作用仅在存在HIV-1 Tat蛋白时才明显，并且需要完整的TAR和TATA框序列。
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