从金钱松中分离并鉴定出四种新型三萜内酯，即假落叶松内酯A、B、C和D。

The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from Pseudolarix kaempferi.

作者信息

Chen G F, Li Z L, Pan D J, Tang C M, He X, Xu G Y, Chen K, Lee K H

机构信息

Department of Chemistry of Natural Drugs, School of Pharmacy, Shanghai Medical University, People's Republic of China.

出版信息

J Nat Prod. 1993 Jul;56(7):1114-22. doi: 10.1021/np50097a015.

DOI:10.1021/np50097a015

PMID:8377017

Abstract

Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharyngeal), A-549 (lung), and HCT-8 (colon), and against a murine leukemia cell line (P-388) with ED50 values of 0.49, 0.67, 0.73, and 0.79 micrograms/ml, respectively.

摘要

从金钱松种子中分离出四种新型三萜内酯，即伪落叶松内酯A [1]、B [2]、C [3]和D [4]。通过光谱数据阐明了它们的结构和立体化学。化合物2对三种人类癌细胞系，即KB（鼻咽癌）、A-549（肺癌）和HCT-8（结肠癌）以及一种小鼠白血病细胞系（P-388）显示出强大的细胞毒性，其半数有效剂量（ED50）值分别为0.49、0.67、0.73和0.79微克/毫升。