[非胰岛素依赖型糖尿病肾病的进展过程——结构与功能的关系]

[Progressive course of nephropathy with non-insulin-dependent diabetes mellitus--structural-functional relationship].

作者信息

Ishihara K, Kanauchi M, Dohi K, Ishikawa H

机构信息

First Department of Internal Medicine, Nara Medical University, Japan.

出版信息

Nihon Jinzo Gakkai Shi. 1993 Jun;35(6):715-22.

PMID:8377284

Abstract

We studied quantitatively a morphological change in diabetic nephropathy by light microscopy. The renal biopsy specimens were examined using color image processor in 53 patients with non-insulin-dependent diabetes mellitus (NIDDM). These patients, aged 22 to 69 years, had been NIDDM for 2 months to 27 years. Glomerular area (GA), mesangial rate (MR) and length of capillary filtration (CFL) were used as the morphological parameters. Duration of diabetes, urinary albumin excretion and creatinine clearance (Ccr) were chosen as clinical manifestations. Duration of diabetes was correlated with MR (r = 0.55, p < 0.01), but not GA. Glomerular hypertrophy could not be found. A significant relationship between Ccr and CFL were noticed (r = 0.64, p < 0.01).

摘要

我们通过光学显微镜对糖尿病肾病的形态学变化进行了定量研究。使用彩色图像处理器对53例非胰岛素依赖型糖尿病（NIDDM）患者的肾活检标本进行了检查。这些患者年龄在22至69岁之间，患NIDDM的时间为2个月至27年。肾小球面积（GA）、系膜比率（MR）和毛细血管滤过长度（CFL）被用作形态学参数。糖尿病病程、尿白蛋白排泄量和肌酐清除率（Ccr）被选为临床表现。糖尿病病程与MR相关（r = 0.55，p < 0.01），但与GA无关。未发现肾小球肥大。注意到Ccr与CFL之间存在显著关系（r = 0.64，p < 0.01）。