Hase H, Nakamura R, Ui K, Imamura Y, Inishi Y, Jyoki N, Yasuda C, Ishikawa H, Yabuki S, Yamaguchi T
3rd Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Nihon Jinzo Gakkai Shi. 1993 Jun;35(6):751-6.
We examined the records of 101 Japanese patients with chronic renal failure (CRF) to determine the influence of established risk factors on the incidence of coronary artery disease (CAD). CAD was found in 25 patients (myocardial infarction in 18, significant coronary artery stenosis by coronary angiogram in 16). In patients with CAD, there were significantly more male (80% vs 58%, p < 0.05), more smokers (80% vs 41%, p < 0.0005), more diabetics (68% vs 32%, p < 0.005) and more hypertensives (92% vs 76%, p < 0.05). However, lipoprotein (a), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or triglycerides were not significantly different between CAD group and control group. When significant risk factors were entered into a stepwise logistic regression analysis, we found a history of smoking (p = 0.0025) and the presence of diabetes (p = 0.0141) to be independent risk factors for the presence of CAD in Japanese patients with CRF.
我们检查了101例日本慢性肾衰竭（CRF）患者的记录，以确定已确定的危险因素对冠状动脉疾病（CAD）发病率的影响。25例患者发现患有CAD（18例心肌梗死，16例经冠状动脉造影显示冠状动脉显著狭窄）。CAD患者中，男性明显更多（80%对58%，p<0.05），吸烟者更多（80%对41%，p<0.0005），糖尿病患者更多（68%对32%，p<0.005），高血压患者更多（92%对76%，p<0.05）。然而，CAD组和对照组之间的脂蛋白（a）、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇或甘油三酯没有显著差异。当将显著危险因素纳入逐步逻辑回归分析时，我们发现吸烟史（p=0.0025）和糖尿病的存在（p=0.0141）是日本CRF患者患CAD的独立危险因素。
