人类的生物学功能是否已经进化以支持更长的寿命？

Have human biological functions evolved in support of a life-span?

作者信息

Weale R A

机构信息

Age Concern Institute of Gerontology, King's College, London, UK.

出版信息

Mech Ageing Dev. 1993 Jun;69(1-2):65-77. doi: 10.1016/0047-6374(93)90072-y.

DOI:10.1016/0047-6374(93)90072-y

PMID:8377530

Abstract

Published data on age-related human biological functions are surveyed. For the many showing a linear decrease, regressions were calculated, or existing functions extrapolated, to yield an intercept on the abscissa. The values of chi(0), the age at which a function ceases, provide a tentative common means of comparison. The distribution of chi(0) is skewed because of the apparent longevity of nervous and cerebral functions. The database is sufficiently large to enable one to distinguish those biological functions which appear to have immediate survival value from those which do not. Such an approach may link biomarkers to estimates of the life-span of species.

摘要

对已发表的有关人类与年龄相关生物功能的数据进行了调查。对于许多呈线性下降的情况，计算了回归方程，或对现有函数进行了外推，以得出横坐标上的截距。函数停止时的年龄χ(0)的值提供了一种初步的通用比较方法。由于神经和大脑功能明显的长寿特性，χ(0)的分布呈偏态。该数据库足够大，能够使人区分出那些似乎具有直接生存价值的生物功能和那些不具有直接生存价值的生物功能。这样一种方法可能会将生物标志物与物种寿命的估计联系起来。