Sanmartí R, Serrarols M, Galinsoga A, Pañella D, Kanterewicz E, Brugués J
Unidad de Reumatología, Hospital General de Vic., Barcelona.
Med Clin (Barc). 1993 Sep 18;101(8):294-7.
There are different diseases which are associated with articular chondrocalcinosis (ACC) although in some it is debated whether this is a real association or an accidental coexistence. The aim of the present study was to analyze the prevalence and type of associated diseases in a series of patients with ACC and to compare with other series in the literature, as well as determine the performance of a protocol directed to the search for such diseases in patients with ACC.
A total of 95 patients diagnosed of ACC and attended in the out patients department of Rheumatology in a general hospital over a 5 year period (1987-1991) were included in a protocol specially designed to search for diseases associated to ACC.
Twelve (13%) of these patients had one of the diseases classically associated to ACC: gout in 8 cases, hypothyroidism in 2 cases and hyperparathyroidism, adult hemochromatosis and hypophosphatasia in one case each (in one patient two of these diseases coexisted). In most of the patients with secondary ACC the coexisting disease had already been diagnosed. Only two patients (one with hypothyroidism and the other with adult hypophosphatasia) were aided by the application of the protocol and were diagnosed having ACC as the only guiding sign.
The number of diseases associated in patients with articular chondrocalcinosis is relatively low. In the absence of clinical suspicion the performance of different laboratory investigations for diagnosis of diseases related with articular chondrocalcinosis is of little benefit.
有多种疾病与关节软骨钙质沉着症（ACC）相关，尽管在某些情况下，对于这是真正的关联还是偶然并存存在争议。本研究的目的是分析一系列ACC患者中相关疾病的患病率和类型，并与文献中的其他系列进行比较，同时确定针对ACC患者寻找此类疾病的方案的效果。
在5年期间（1987 - 1991年），共有95名被诊断为ACC且在综合医院风湿病门诊就诊的患者被纳入一项专门设计用于寻找与ACC相关疾病的方案。
这些患者中有12名（13%）患有与ACC经典相关的疾病之一：痛风8例，甲状腺功能减退2例，甲状旁腺功能亢进、成人血色素沉着症和低磷酸酯酶症各1例（1例患者同时存在其中两种疾病）。在大多数继发性ACC患者中，并存疾病已被诊断出来。只有2例患者（1例甲状腺功能减退，另1例成人低磷酸酯酶症）通过该方案得到帮助，并以ACC作为唯一指导体征被诊断出来。
关节软骨钙质沉着症患者中相关疾病的数量相对较少。在没有临床怀疑的情况下，进行不同实验室检查以诊断与关节软骨钙质沉着症相关疾病的效果甚微。
