Pons F W, Adler-Bollinger A, Müller P
Institut für Mikrobiologie, J.W. Goethe-Universität, Frankfurt-am-Main, FRG.
Mutagenesis. 1993 Jul;8(4):295-9. doi: 10.1093/mutage/8.4.295.
When bacteria were treated simultaneously with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and low concentrations of 9-aminoacridine (9AA), the yield of frameshift mutations was much greater than that expected on the basis of independent action of both mutagens. In combination with a high concentration of 9AA, however, MNNG had an antagonistic effect upon the induction of frameshift mutations. There was no synergistic interaction between the two mutagens in bacteria in which the adaptive response to methylating agents had been induced. 9AA not only induced frameshift mutations, but also caused a small increase in reversions of a nonsense (ochre) mutation and, in combination with low MNNG concentrations, it had a small synergistic effect.
当细菌同时用N-甲基-N'-硝基-N-亚硝基胍（MNNG）和低浓度的9-氨基吖啶（9AA）处理时，移码突变的发生率远高于基于两种诱变剂独立作用所预期的发生率。然而，与高浓度的9AA联合使用时，MNNG对移码突变的诱导具有拮抗作用。在已诱导出对甲基化剂适应性反应的细菌中，这两种诱变剂之间没有协同相互作用。9AA不仅诱导移码突变，还使无义（赭石型）突变的回复率略有增加，并且与低浓度的MNNG联合使用时，具有轻微的协同效应。
