Pieper D R, Lobocki C A
Department of Physiology and Research, Providence Hospital, Southfield, MI 48037.
Neurosci Lett. 1993 Jun 11;155(2):227-9. doi: 10.1016/0304-3940(93)90714-v.
Olfactory bulbectomy results in a marked increase in gonadotropin secretion and prevents the reproductive regression associated with short photoperiod when the olfactory bulbectomy is done before exposure to the inhibitory photoperiod. The present study tested whether olfactory bulbectomy would offset the influence of short photoperiod if done after the reproductive system had regressed. Adult golden hamsters Mesocricetus auratus were divided into four groups: early sham (surgery at week-4); early olfactory bulbectomy (surgery at week-4); late sham (surgery at week 14) and late olfactory bulbectomy (surgery at week 14). At t = 0, all golden hamsters were placed in a short photoperiod (L:D 10:14). Early olfactory bulbectomy prevented testicular regression; the late olfactory bulbectomy group recrudesced much earlier than the sham groups. These results indicate that the tonic inhibitory influence of the olfactory bulbs is required for initiation of short photoperiod induced testicular regression and is also essential for the maintenance of the regressed state.
当在暴露于抑制性光周期之前进行嗅球切除时，嗅球切除会导致促性腺激素分泌显著增加，并防止与短光周期相关的生殖功能衰退。本研究测试了如果在生殖系统已经衰退后进行嗅球切除，是否会抵消短光周期的影响。成年金黄地鼠（Mesocricetus auratus）被分为四组：早期假手术组（第4周手术）；早期嗅球切除组（第4周手术）；晚期假手术组（第14周手术）和晚期嗅球切除组（第14周手术）。在t = 0时，所有金黄地鼠都被置于短光周期（光照：黑暗10:14）中。早期嗅球切除可防止睾丸衰退；晚期嗅球切除组比假手术组更早恢复。这些结果表明，嗅球的紧张性抑制作用是短光周期诱导睾丸衰退起始所必需的，对于维持衰退状态也至关重要。
