Nishihara K, Tsuneyoshi M, Ohshima A, Yamaguchi K
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pathol Res Pract. 1993 Jun;189(5):521-6. doi: 10.1016/S0344-0338(11)80359-6.
In order to attempt to examine the question of whether papillary cystic tumors (PCT) of the pancreas represent a hormone-dependent neoplasm or not, three cases of PCT were biochemically and immunohistochemically investigated. The patients included a 27-year-old man, a 14-year-old girl and a 21-year-old female. Two of the three patients showed measurable biochemical levels of progesterone receptor in the tumors by the dextran-coated charcoal (DCC) method, and an immunohistochemical study revealed that the nuclei of the tumor cells in all the three cases were diffusely positive for progesterone receptor. In the literature, there have been more than 300 female patients of PCT with a significant minority of only twenty male patients, and the mean age of the cases with PCT in men (31.4 years old) is higher than that in women (25.5 years old) (P < 0.05). These results therefore suggest that PCT is a sex hormone-dependent neoplasm.
为了探讨胰腺乳头状囊性肿瘤（PCT）是否为激素依赖性肿瘤这一问题，对3例PCT患者进行了生化和免疫组化研究。患者包括一名27岁男性、一名14岁女孩和一名21岁女性。通过葡聚糖包被活性炭（DCC）法，3例患者中有2例肿瘤组织中可检测到孕酮受体的生化水平，免疫组化研究显示，所有3例患者肿瘤细胞的细胞核均呈孕酮受体弥漫性阳性。在文献中，PCT患者有300多名女性，仅有少数20名男性患者，男性PCT患者的平均年龄（31.4岁）高于女性（25.5岁）（P<0.05）。因此，这些结果提示PCT是一种性激素依赖性肿瘤。
