B6C3F1小鼠自发性卵巢绒毛膜癌、卵黄囊癌和畸胎瘤：一例报告

Spontaneous ovarian choriocarcinoma, yolk sac carcinoma, and teratoma in B6C3F1 mice: a case report.

作者信息

Frith C H, Evans M G

机构信息

Toxicology Pathology Associates, Little Rock, Arkansas 72211.

出版信息

Toxicol Pathol. 1993;21(1):91-8. doi: 10.1177/019262339302100112.

DOI:10.1177/019262339302100112

PMID:8378711

Abstract

Three ovarian neoplasms (choriocarcinoma, yolk sac carcinoma, and teratoma) were diagnosed in a 2 yr carcinogenicity study involving B6C3F1 mice. The yolk sac carcinoma and the teratoma occurred in opposite ovaries of a single female mouse that was sacrificed in extremis on study day 725. The choriocarcinoma occurred in a female mouse that was sacrificed in extremis on study day 565. These neoplasms were considered to be spontaneous in origin.

摘要

在一项为期2年的B6C3F1小鼠致癌性研究中，诊断出3例卵巢肿瘤（绒毛膜癌、卵黄囊癌和畸胎瘤）。卵黄囊癌和畸胎瘤发生在一只雌性小鼠的双侧卵巢，该小鼠在研究第725天时濒死处死。绒毛膜癌发生在一只雌性小鼠，该小鼠在研究第565天时濒死处死。这些肿瘤被认为是自发产生的。