促甲状腺激素对甲状腺中鸟氨酸脱羧酶的作用以及多胺对甲状腺中RNA聚合酶的作用。
Effect of thyrotropin on ornithine decarboxylase and of polyamines on RNA polymerase in the thyroid.
作者信息
Spaulding S W
出版信息
Endocrinology. 1977 Apr;100(4):1039-46. doi: 10.1210/endo-100-4-1039.
PMID:837873
Abstract
Two major forms of RNA polymerase were partially purified from calf thyroid nuclei. Type I showed greatest activity in 30 mM(NH4)2SO4, transcribed native DNA best and was resistant to the inhibitor alpha-amanitin. Type II showed greatest activity in 100 mM(NH4)2SO4, transcribed denatured DNA template best and was sensitive to low concentrations of alpha-amanitin...
摘要
从牛甲状腺细胞核中部分纯化出了两种主要形式的RNA聚合酶。I型在30 mM硫酸铵中表现出最大活性，对天然DNA的转录效果最佳，且对抑制剂α-鹅膏蕈碱具有抗性。II型在100 mM硫酸铵中表现出最大活性，对变性DNA模板的转录效果最佳，并且对低浓度的α-鹅膏蕈碱敏感……
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