Tashiro J, Nishide T, Shinomiya M, Shirai K, Saito Y, Yoshida S, Yamashita M, Ohshima H, Murayama H
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Scand J Clin Lab Invest. 1993 Jul;53(4):335-8. doi: 10.3109/00365519309086624.
The relationship between coronary stenosis and 'midband' lipoprotein, which was observed between low density lipoproteins and very low density lipoproteins by 3% polyacrylamide gel electrophoresis, was studied in patients with heterozygous familial hypercholesterolaemia (FH). The subjects were 46 patients with FH, who were evaluated by coronary angiography. The groups with and without coronary artery disease (CAD) were compared. Age, sex ratio, total cholesterol, triglyceride, HDL-cholesterol and lipoprotein(a) levels were matched in these two groups. In addition, Achilles tendon thickness and the incidence of risk factors such as diabetes mellitus, hypertension and smoking between these two groups were matched. Under these conditions, the frequency of midband was higher in the patients with CAD (20/26) than that in patients without (4/20). The results suggest that the presence of a midband among Japanese is an independent risk factor for coronary stenosis even in cases of FH who have severe hypercholesterolaemia.
通过3%聚丙烯酰胺凝胶电泳在低密度脂蛋白和极低密度脂蛋白之间观察到的冠状动脉狭窄与“中带”脂蛋白之间的关系，在杂合子家族性高胆固醇血症（FH）患者中进行了研究。研究对象为46例经冠状动脉造影评估的FH患者。对有和没有冠状动脉疾病（CAD）的两组进行了比较。这两组在年龄、性别比例、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和脂蛋白（a）水平方面相匹配。此外，这两组在跟腱厚度以及糖尿病、高血压和吸烟等危险因素的发生率方面也相匹配。在这些条件下，CAD患者中中带的频率（20/26）高于无CAD患者（4/20）。结果表明，即使在患有严重高胆固醇血症的FH病例中，日本人中存在中带也是冠状动脉狭窄的一个独立危险因素。
