Broene R D, Buchwald S L
Department of Chemistry, Massachusetts Insitute of Technology, Cambridge 02139.
Science. 1993 Sep 24;261(5129):1696-701. doi: 10.1126/science.8378769.
Transition metals are known to stabilize high-energy species and to activate otherwise unreactive ones. The zirconocene unit stabilizes highly strained alkynes and alkenes, allowing their use in selective carbon-carbon bond-forming reactions. This unit also increases the reactivity of unactivated molecules, enabling them to participate in nontraditional transformations. A general route has been developed that allows a wider variety of unsaturated fragments to participate in these reactions. The use of these zirconocene complexes in organic synthesis has led to the development of novel routes to a number of polyfunctionalized organic molecules.
已知过渡金属能稳定高能物种并活化原本不活泼的物种。二茂锆单元能稳定高张力的炔烃和烯烃，使其可用于选择性碳-碳键形成反应。该单元还能提高未活化分子的反应活性，使其能够参与非传统转化反应。现已开发出一条通用路线，能让更多种类的不饱和片段参与这些反应。这些二茂锆配合物在有机合成中的应用已催生出多种多官能化有机分子的新合成路线。
