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[中毒性肺炎和急性呼吸衰竭的毒理学评估]

[A toxicometric assessment of pneumonias and acute respiratory failure in poisonings].

作者信息

Iskandarov A I

出版信息

Sud Med Ekspert. 1993 Jul-Sep;36(3):23-5.

PMID:8378975
Abstract

The author analyzes clinical and morphologic manifestations of pneumonia and the conditions under which acute respiratory failure formed in 572 subjects who suffered poisoning with psychotropic and soporific drugs, chlorinated hydrocarbons, organophosphorus insecticides, caustic poisons, alcohol and its surrogates. Toxicometric (quantitative) assessment of the toxic effects and measurement of the toxins concentrations under which respiratory failure developed helped detect new mechanisms in the patho- and thanatogenesis of pneumonias and acute respiratory failure in poisonings. These data are of great interest for practical forensic medicine, since they permit substantiating the causes of death in various types of poisonings. The diagram proposed by the author permits assessment of the initial chemical trauma from the clinical and morphologic picture of poisoning.

摘要

作者分析了572名因精神药物、安眠药、氯代烃、有机磷杀虫剂、腐蚀性毒物、酒精及其替代品中毒的患者的肺炎临床和形态学表现,以及急性呼吸衰竭形成的条件。对中毒时的毒性作用进行毒理学(定量)评估并测量毒素浓度,有助于发现中毒性肺炎和急性呼吸衰竭发病机制及死因形成过程中的新机制。这些数据对实际法医学具有重要意义,因为它们有助于证实各类中毒的死亡原因。作者提出的图表可根据中毒的临床和形态学表现评估初始化学损伤情况。

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