Miyamoto O, Itano T, Fujisawa M, Tokuda M, Matsui H, Nagao S, Hatase O
Department of Physiology, Kagawa Medical School, Japan.
Acta Med Okayama. 1993 Jun;47(3):139-44. doi: 10.18926/AMO/31596.
Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were administered into the rat brain following unilateral fimbria-fornix transection. Both bFGF and NGF stimulated the sprouting of acetylcholinesterase (AChE) positive fibers in the hippocampus on the lesioned side. Furthermore, a small number of AChE-positive fibers were regenerated even when only the vehicle was administered. Rats treated with NGF as well as control group had only thin fibers, whereas those treated with bFGF had not only thin fibers but also thick fibers. These results indicate that intrinsic NGF is released and acts on damaged neurons directly, while bFGF acts them on directly and/or indirectly after brain injury.
在大鼠单侧穹窿-海马伞横断后，将碱性成纤维细胞生长因子（bFGF）和神经生长因子（NGF）注入大鼠脑内。bFGF和NGF均刺激了损伤侧海马中乙酰胆碱酯酶（AChE）阳性纤维的发芽。此外，即使仅给予赋形剂，也有少量AChE阳性纤维再生。用NGF治疗的大鼠以及对照组只有细纤维，而用bFGF治疗的大鼠不仅有细纤维，还有粗纤维。这些结果表明，内源性NGF被释放并直接作用于受损神经元，而bFGF在脑损伤后直接和/或间接作用于它们。
