6-羟基多巴胺处理的大鼠中卡马西平抗惊厥活性降低。
Decreased anticonvulsant activity of carbamazepine in 6-hydroxydopamine-treated rats.
作者信息
Quattrone A, Samanin R
出版信息
Eur J Pharmacol. 1977 Feb 7;41(3):336-6. doi: 10.1016/0014-2999(77)90327-2.
PMID:837975
Abstract
An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of catecholamines in the forebrain, significantly lowered the electroconvulsive threshold in rats. The anticonvulsant effect of carbamazepine was also significantly reduced in the animals treated with 6-hydroxydopamine. The results are consistent with the hypothesis that brain catecholamines may play an important role in seizure susceptibility as well as in the anticonvulsant activity of carbamazepine in rats.
摘要
脑室内注射6-羟基多巴胺可使前脑中的儿茶酚胺显著减少，这也显著降低了大鼠的电惊厥阈值。在接受6-羟基多巴胺治疗的动物中，卡马西平的抗惊厥作用也显著降低。这些结果与以下假设一致，即脑内儿茶酚胺可能在大鼠的癫痫易感性以及卡马西平的抗惊厥活性中发挥重要作用。
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