Effects of epidermal growth factor on mouse fetal growth.

The effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal-plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine. These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.