大鼠在发育过程中接触苯二氮䓬受体拮抗剂氟马西尼所产生的行为变化。

Behavioral changes produced in rats by developmental exposure to flumazenil, a benzodiazepine receptor antagonist.

Cagiano R, De Salvia M A, Giustino A, Lacomba C, Cuomo V

Institute of Pharmacology, University of Bari, Italy.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Jan;17(1):151-9. doi: 10.1016/0278-5846(93)90039-u.

Abstract

Prolonged administration of a benzodiazepine receptor antagonist, such as flumazenil (given to the mother at a dose of 3 mg/kg s.c. from day 14 to day 20 of gestation), produced subtle behavioral changes in rat pups. 2. Flumazenil treatment decreased the rate of ultrasonic vocalization in 15-day old male pups removed from their nest. 3. No significant changes in the locomotor activity of the flumazenil-treated group with respect to controls was found at the end of the second and fourth postnatal week. 4. These results suggest that late prenatal exposure to flumazenil induces in rat offspring behavioral changes characterized by decreased emotional responsiveness to environmental challenges.

摘要

长期给予苯二氮䓬受体拮抗剂，如氟马西尼（在妊娠第14天至第20天以3mg/kg的剂量皮下注射给母鼠），会使幼鼠出现细微的行为变化。2. 氟马西尼处理降低了从巢中取出的15日龄雄性幼鼠的超声波发声率。3. 在出生后第二周和第四周结束时，未发现氟马西尼处理组的运动活动相对于对照组有显著变化。4. 这些结果表明，产前晚期接触氟马西尼会在大鼠后代中诱发行为变化，其特征是对环境挑战的情绪反应性降低。