Ducheyne P, Radin S, King L
Department of Bioengineering, University of Pennsylvania, Philadelphia 19104.
J Biomed Mater Res. 1993 Jan;27(1):25-34. doi: 10.1002/jbm.820270105.
Synthetic calcium phosphate ceramic (CPC) surfaces can be transformed to a biological apatite through a sequence of reactions which include dissolution, precipitation, and ion exchange. By virtue of the reactions being material-dependent, it is important to determine parametric rate effects. In this study we focused on the effect of stoichiometry and crystal structure of CPCs on the dissolution kinetics. Monophase, biphase, and multiphase CPCs with a Ca/P ratio equal to or greater than 1.5 were studied. The experiments were performed in a calcium- and phosphate-free Tris buffer solution at pH 7.3. The dissolution behavior of the CPCs studied was found to vary over a wide range. The dissolution rate of the monophase CPCs increased in the order of stoichiometric hydroxyapatite, calcium deficient hydroxyapatite, oxyhydroxyapatite, beta-tricalcium phosphate, alpha-tricalcium phosphate, and tetracalcium phosphate. Dissolution of biphase and multiphase CPCs increased prorated the concentration of more soluble component.
合成磷酸钙陶瓷（CPC）表面可通过一系列反应转化为生物磷灰石，这些反应包括溶解、沉淀和离子交换。由于这些反应取决于材料，确定参数速率效应很重要。在本研究中，我们重点关注了CPC的化学计量比和晶体结构对溶解动力学的影响。研究了钙磷比等于或大于1.5的单相、双相和多相CPC。实验在pH 7.3的无钙和无磷酸盐的Tris缓冲溶液中进行。所研究的CPC的溶解行为在很宽的范围内变化。单相CPC的溶解速率按化学计量比羟基磷灰石、缺钙羟基磷灰石、羟基氧磷灰石、β-磷酸三钙、α-磷酸三钙和磷酸四钙的顺序增加。双相和多相CPC的溶解随更易溶成分浓度的增加而成比例增加。
