Aguglia U, Oliveri R L, Gambardella A, Quattrone A
Institute of Neurological Sciences, School of Medicine, University of Reggio Calabria Catanzaro, Italy.
J Neurol. 1993 Jan;240(1):25-7. doi: 10.1007/BF00838442.
We evaluated the effects of flumazenil (FMZ), a high-affinity benzodiazepine receptor antagonist, on flash-evoked visual potentials (FEPs) in a patient with Creutzfeldt-Jacob disease (CJD). FEPs were recorded in three different consecutive sessions: (1) basal condition, without any pharmacological treatment; (2) 3.5 min after i.v. administration of 5 mg FMZ; (3) 1 min after i.v. administration of 10 mg diazepam (DZP). FMZ provoked a marked increase in the amplitude as well as evident shortening of the latency of early FEP components. DZP reversed these effects. These results are in agreement with our previous findings of anatomical and functional integrity of the geniculo-striate pathways in human CJD and demonstrate functional integrity of benzodiazepine receptors in this visual system in CJD.
我们评估了高亲和力苯二氮䓬受体拮抗剂氟马西尼（FMZ）对一名克雅氏病（CJD）患者闪光视觉诱发电位（FEP）的影响。在连续三个不同的时间段记录FEP：（1）基础状态，未进行任何药物治疗；（2）静脉注射5 mg FMZ后3.5分钟；（3）静脉注射10 mg地西泮（DZP）后1分钟。FMZ使早期FEP成分的振幅显著增加，潜伏期明显缩短。DZP逆转了这些效应。这些结果与我们之前关于人类CJD中膝状体-纹状体通路解剖和功能完整性的研究结果一致，并证明了CJD这种视觉系统中苯二氮䓬受体的功能完整性。
