4-甲氧基-2-甲基四氢吡喃：手性白三烯生物合成抑制剂，与ICI D2138相关，具有对映选择性。 - Suppr

Suppr

超能文献

4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.

作者信息

Crawley G C, Briggs M T, Dowell R I, Edwards P N, Hamilton P M, Kingston J F, Oldham K, Waterson D, Whalley D P

机构信息

Chemistry 1 Department, ICI Pharmaceuticals, Mereside, Macclesfield, Cheshire, UK.

出版信息

J Med Chem. 1993 Jan 22;36(2):295-6. doi: 10.1021/jm00054a016.

DOI:10.1021/jm00054a016

PMID:8380872

Abstract

摘要

相似文献

4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.4-甲氧基-2-甲基四氢吡喃：手性白三烯生物合成抑制剂，与ICI D2138相关，具有对映选择性。

J Med Chem. 1993 Jan 22;36(2):295-6. doi: 10.1021/jm00054a016.

Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.ICI D2138的临床前药理学，一种强效口服活性5-脂氧合酶非氧化还原抑制剂。

Br J Pharmacol. 1992 Dec;107(4):1042-7. doi: 10.1111/j.1476-5381.1992.tb13404.x.

Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.导致发现ICI D2138（一种5-脂氧合酶的选择性、强效且口服活性抑制剂）的结构与活性关系。

J Lipid Mediat. 1993 Mar-Apr;6(1-3):249-57.

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.

J Med Chem. 1992 Jul 10;35(14):2600-9. doi: 10.1021/jm00092a010.

Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase.新型咪唑化合物作为一类新的强效、口服活性5-脂氧合酶抑制剂。

Bioorg Med Chem. 2003 Sep 1;11(18):3879-87. doi: 10.1016/s0968-0896(03)00436-x.

Chiral dioxolane inhibitors of leukotriene biosynthesis: structure-activity relationships and syntheses using asymmetric dihydroxylation.

J Med Chem. 1995 Sep 29;38(20):3951-6. doi: 10.1021/jm00020a008.

5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.

Bioorg Med Chem Lett. 2005 May 16;15(10):2611-5. doi: 10.1016/j.bmcl.2005.03.041.

Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.白三烯合成抑制剂BAY x1005对豚鼠气道抗原诱导收缩的抑制作用

Eur J Pharmacol. 1994 Jun 2;258(1-2):95-102. doi: 10.1016/0014-2999(94)90061-2.

Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.

J Med Chem. 1994 Feb 18;37(4):512-8. doi: 10.1021/jm00030a010.

The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.5-脂氧合酶抑制剂ZD2138和ZM230487是几种抗原诱导的豚鼠肺部反应的强效和选择性抑制剂。

Eur J Pharmacol. 1994 May 23;257(3):285-92. doi: 10.1016/0014-2999(94)90140-6.

引用本文的文献

Unexpected Substituent Effects in Spiro-Compound Formation: Steering -Aryl Propynamides and DMSO toward Site-Specific Sulfination in Quinolin-2-ones or Spiro[4,5]trienones.螺环化合物形成中的意外取代基效应：导向-芳基丙炔酰胺和 DMSO 实现喹啉-2-酮或螺[4,5]三烯酮中特定位置的磺化反应。

J Org Chem. 2021 Jul 16;86(14):9490-9502. doi: 10.1021/acs.joc.1c00775. Epub 2021 Jun 29.

Effect of a 5-lipoxygenase inhibitor, ZM 230487, on cutaneous allergic inflammation in the guinea-pig.5-脂氧合酶抑制剂ZM 230487对豚鼠皮肤过敏性炎症的影响。

Br J Pharmacol. 1994 Apr;111(4):1205-11. doi: 10.1111/j.1476-5381.1994.tb14873.x.

Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators.豚鼠皮肤反向被动Arthus反应中炎症反应相关机制的研究：中性粒细胞和内源性介质的作用

Br J Pharmacol. 1994 Dec;113(4):1363-71. doi: 10.1111/j.1476-5381.1994.tb17148.x.

Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.P物质诱导的豚鼠皮肤炎症反应：特异性NK1受体拮抗剂的作用及内源性介质的作用

Br J Pharmacol. 1995 Apr;114(7):1343-50. doi: 10.1111/j.1476-5381.1995.tb13354.x.

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