Bar J, Tepper R, Fuchs J, Pardo Y, Goldberger S, Ovadia J
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah Tiqva, Israel.
Obstet Gynecol. 1993 Feb;81(2):261-4.
To evaluate the effect of hormone replacement therapy on platelet function in postmenopausal women.
In 51 postmenopausal women, platelet aggregation and adenosine triphosphate (ATP) release were studied before and after estrogen and progestogen treatment and compared with that in untreated patients. An incubation study evaluated platelet function after incubation with estrogen and progestogen.
Significant decreases in adrenaline-induced platelet aggregation (P < .01) and ATP release (P < .02) were observed 3 months after initiation of estrogen replacement. Patients receiving replacement regimens consisting of estrogen opposed by progestogen or progestogen alone showed nonsignificant changes in platelet aggregation and release. The most pronounced decrease in platelet function in the incubation assay was detected after incubation with estrogen plus progestogen. Results were similar in the spontaneous- and surgical-menopause patients.
Estrogen replacement therapy may inhibit the atherosclerotic process by suppressing platelet function.
评估激素替代疗法对绝经后女性血小板功能的影响。
对51名绝经后女性，在雌激素和孕激素治疗前后研究血小板聚集和三磷酸腺苷（ATP）释放情况，并与未治疗患者进行比较。一项孵育研究评估了雌激素和孕激素孵育后血小板的功能。
雌激素替代治疗开始3个月后，观察到肾上腺素诱导的血小板聚集（P < 0.01）和ATP释放（P < 0.02）显著降低。接受雌激素加孕激素或单独孕激素替代方案的患者，血小板聚集和释放无显著变化。在孵育试验中，与雌激素加孕激素孵育后检测到血小板功能下降最为明显。自然绝经和手术绝经患者的结果相似。
雌激素替代疗法可能通过抑制血小板功能来抑制动脉粥样硬化进程。
