Dmowski W P, Shih A, Wilhelm J, Auletta F, Scommegna A
Fertil Steril. 1977 Mar;28(3):262-8.
The effect of intrauterine estriol on spontaneous ovulation, ovum fertilization, blastocyst development, and blastocyst implantation in rabbits has been investigated. Estriolreleasing intrauterine capsules constructed of biocompatible polymer were implanted in one uterine horn of adult New Zealand White female rabbits, while placebo-containing capsules were implanted into the contralateral horn. The animals were artificially inseminated and ovulated or mated to fertile bucks. The does were killed and their reproductive tracts were examined 54 hours, 6 days, and 10 days after ovulation-inducing injection or after coitus. The results indicate that intrauterine estriol released at a steady state rate of 1.25 mug/day effectively inhibits blastocyst development and implantation. This contraceptive effect was clearly local, since implantations in the contralateral,placebo-bearing horn were not inhibited. Furthermore, the same dose of estriol, when released systemically from a subcutaneously placed capsule, had no effect on implantation. Intrauterine estriol appeared also to have no effect on spontaneous ovulation or ovum fertilization.
已对兔子宫内雌三醇对自发排卵、卵子受精、囊胚发育及囊胚着床的影响进行了研究。将由生物相容性聚合物制成的释放雌三醇的子宫内胶囊植入成年新西兰白兔雌性的一侧子宫角，而将含安慰剂的胶囊植入对侧子宫角。对动物进行人工授精并使其排卵，或与可育雄兔交配。在诱导排卵注射后或交配后54小时、6天和10天处死母兔并检查其生殖道。结果表明，以1.25微克/天的稳定速率释放的子宫内雌三醇可有效抑制囊胚发育及着床。这种避孕作用明显是局部性的，因为对侧含安慰剂子宫角的着床未受抑制。此外，相同剂量的雌三醇从皮下植入的胶囊全身释放时，对着床没有影响。子宫内雌三醇似乎对自发排卵或卵子受精也没有影响。
