Malacarne P, Castaldi G, Bertusi M, Zavagli G
Diabetes. 1977 Feb;26(2):156-8. doi: 10.2337/diab.26.2.156.
A 67-year-old female diabetic is presented who developed a Coombs'-positive hemolytic anemia after a year of treatment with tolbutamide. An IgG antibody was identified in the patient's serum that caused the agglutination of both the patient's red blood cells and tolbutamide-coated erythrocytes in the absence of complement. Such a reaction did not occur with the patient's erythrocytes when not exposed to tolbutamide. Agglutination of the patient's serum also occurred with erythrocytes treated with other sulfonylureas (chlorpropamide, glibenclamide, carbutamide) but not with phenacetin.
一名67岁的女性糖尿病患者，在接受甲苯磺丁脲治疗一年后出现了抗人球蛋白试验阳性的溶血性贫血。在患者血清中鉴定出一种IgG抗体，该抗体在无补体的情况下可导致患者红细胞和甲苯磺丁脲包被的红细胞发生凝集。当患者的红细胞未接触甲苯磺丁脲时，不会发生这种反应。患者血清与其他磺脲类药物（氯磺丙脲、格列本脲、氨磺丁脲）处理过的红细胞也会发生凝集，但与非那西丁处理过的红细胞不发生凝集。
